I like glycerin suppositories. I have a jar of Fleet suppositories that I use several times a week. I have found if I do use them for 5-6 days consecutively, I will experience some irritation inside my rectum. So I now space my suppository mornings a few days apart.
I do like the effect- I can go (BM) rather easily and quickly. I liked them so much that is why I think I got to a point where they did begin to cause some irritation.
I guess you can get too much of a good thing!