After reading all the comments about a better feeling of well-being after enemas, I am becoming convinced that the 80%=90% of serotonin that is stored in the large intestine may be released to some extent by irrigation of the colon. The serotonin enters the bloodstream and travels to the brain, where the new feelings of well-being result.
It's been proven that elevating serotonin levels at the synapses in the brain, improves depression. All of the research has been done with oral medications to achieve that. If anyone would try to achieve this by colon stimulation in a research setting, I'm afraid the results would be like the study Columbia U. Hosp. did with coffee enemas detoxifying the pancreas; it was stopped because of patient dropout. It was neither proved, nor disproved.
The additives to the irrigating solution should make no difference, if trying to get serotonin to release from the large bowel. If someone could prove that daily enemas accomplished the same thing as daily doses of Lexapro, or any other of the newer antidepressants (which are expensive), I believe that patient acceptance would be for taking a pill, rather than enemas. Yes, lots of money could be saved by the patient, but who has the time to irrigate daily, if they have a job and family responsibilities? Non-Klysmo. people would just NOT do it.
The only non-pharmaceutical attempt to treat depression was done by a local psychiatric hospital, which used vigorous physical exercise to improve depressed patients. The Psych's were honest enough to admit that they were getting endorphin releases that made the patients feel better for a short time.